Pharmacometrics Center of Excellence

The Pharmacometrics Center of Excellence is a consortium of investigators with wide scientific expertise in Pharmacometrics, Clinical Pharmacology, and Drug Design. Our investigators have broad expertise in pre-clinical through post-marketing studies.

Research Lab

Ƶ the MWUPCE

The Ƶ Pharmacometrics Center of Excellence (MWUPCE) partners strong faculty knowledge base in computer modeling of drug efficacy and toxicity with wet-lab analytic approaches. Together, the group is highly expert conducting pre-clinical through post-marketing studies. The Center builds on the existing synergies in the University's Core Facilities.

Learn more about the Downers Grove Core Research Facility

Mission

The mission of the MWUPCE is to:

  • Design innovative strategies that maximize safe and effective pharmacotherapy for patients
  • Develop the next generation of translational clinicians and scientists through advanced pharmacometric education.

Meet the Investigators
 

Pharmacometrics team examine slide.

 

Meet the Investigators

Dr. Andurkar serves as Professor and Chair of the Department of Pharmaceutical Sciences. He earned his M.S. and Ph.D. in Medicinal Chemistry from Auburn University, Department of Pharmaceutical Sciences. He completed his postdoctoral studies at the University of Houston, Department of Chemistry. Dr. Andurkar has more than 25 years of experience in the design, synthesis, isolation and purification, structural elucidation, drug metabolism, and pharmacological studies of bioactive molecules. His current research interests are in the design, synthesis, and pharmacological evaluation of novel analgesics and antiepileptic agents, as well as the study of novel synthetic organic chemical methodologies, stereoselective synthesis, and evaluating the impact of stereochemistry on biological activity. He serves as scientific advisor to Aagami Inc., and Pharmazz Inc.

Shridhar Andurkar

Dr. Spencer Harris is an Infectious Diseases Translational Research Fellow at Ƶ College of Pharmacy-Glendale Campus, and he is a member of the Pharmacometrics Center of Excellence. He practices as an Infectious Diseases pharmacist at HonorHealth John C. Lincoln Medical Center in Phoenix, AZ. He obtained his Doctor of Pharmacy in 2022 at the University of Mississippi and completed a PGY-1 Pharmacy Practice Residency at Baptist Memorial Hospital – DeSoto in Southaven, MS. He is engaged in both clinical and in vitro research focusing on Clostridioides difficile and multidrug-resistant Acinetobacter baumannii. He serves on multiple organizations’ task forces and committees.

Spencer Harris.

Dr. Medha D. Joshi is an Associate Professor in Pharmaceutical Sciences at Ƶ's College of Pharmacy, Glendale Campus. Dr. Joshi has expertise in lipid based drug delivery systems including solid lipid nanoparticles (SLN), micro emulsions, self-emulsifying drug delivery systems (SMEDDs), nanosuspensions, and liposomes etc. targeted drug delivery. Her research program at Ƶ university is focused on application of nanoparticulate targeted delivery a) to neurogenetic peptides for their delivery to the blood brain barrier, and b) reduction of maternal-fetal toxicity of drugs across the placental barrier. She has more than 30 peer-reviewed research articles, two patents, and three book chapters to her credit. She has been a principle investigator and co-investigator on several intramural and extramural grants, including the Alzheimer's Drug Discovery Foundation and NIH AREA grants.

Medha Joshi posing in front of a scenic landscape with trees and a birdbath

Dr. Gwendolyn Pais is a Research Assistant Professor in the College of Pharmacy and a Scientist within the Ƶ Pharmacometrics Center of Excellence. Dr. Pais earned her Ph.D. from the University of Illinois at Chicago. She completed her postdoctoral training in Pharmacology at Ƶ. Her research focuses on preventing drug-induced kidney and neurologic toxicity. She is particularly interested in defining optimal exposures, exposure thresholds and biomarkers of toxicity to facilitate dose escalation in a safe manner. Her laboratory utilizes non-clinical approaches and seeks to translate these data to critically ill pediatric patients. Dr. Pais is actively engaged in pharmacology organizations and serves as a reviewer for multiple peer-reviewed journals.

Gwendolyn Pais

Dr. Justin Shiau is an Infectious Diseases Pharmacotherapy fellow at Ƶ and a member of the Pharmacometrics Center of Excellence and practices clinically at Northwestern Memorial Hospital. He obtained his Doctor of Pharmacy degree from Southern Illinois University Edwardsville School of Pharmacy in 2022. He then went on to complete a PGY-1 Pharmacy Practice Residency at Northwestern Medicine Central DuPage Hospital. Dr. Shiau's interest areas include antimicrobial stewardship, treatment of multi-drug resistant infections, drug-induced toxicity, and pharmacy academia. Currently, he is actively engaged in various activities including clinical data pharmacokinetic modeling of antibiotics and serving in various committees for infectious disease pharmacy organizations.

Dr. Justin Shiau

Dr. Zurawska is a postdoctoral fellow at Ƶ in Downers Grove, with a focus on the application of mass spectrometry for the analysis of small molecules in infectious disease research. She obtained her Doctor of Pharmacy degree in Bari, Italy, and gained hand’s on research experience in the laboratory of Prof. Ferdinando Palmieri studying mitochondrial transporter proteins. She received her PhD in Biochemistry and Biophysics in Warsaw, Poland under the supervision of Prof. Michal Dadlez. She has expertise in mass spectrometry-based proteomics to study biomarkers for sensitivity to CDK-4/6 inhibitors in breast cancer, targeted proteomic analyzes, LC-MS PRM, MRM, and global proteomics approaches. She studied the GSTP1 protein which is important in breast cancer at the Division of Oncology at Washington University in St. Louis. Her research interests center on the translational application of mass spectrometry and multi-omics approaches as tools to achieve personalized medicine.

Marta Zurawska.

Previous Publications and Presentations

Miglis C, Rhodes NJ, Liu J, Gener J, Hang E, Scheetz M. Quantifying the Importance of Active Antimicrobial Therapy among Patients with Gram-negative Bloodstream Infections: Cefepime as a Representative Agent. International Journal of Antimicrobial Agents. 2018. Epub 2018/10/14. doi: 10.1016/j.ijantimicag.2018.10.004. PubMed PMID: 30315921.

Avedissian SN, Scheetz MH, Zembower TR, Silkaitis C, Maxwell R, Jenkins C, Postelnick MJ, Sutton SH, Rhodes NJ. Measuring the impact of varying denominator definitions on standardized antibiotic consumption rates: implications for antimicrobial stewardship programmes. Journal of Antimicrobial Chemotherapy. 2018;73(10):2876-82. Epub 2018/08/08. doi: 10.1093/jac/dky275. PubMed PMID: 30085084.

Joshi M, Chang J., Hlukhenka K., Pais G., Avedissian S., Gulati A., Prozialeck W, Hubka T., Scheetz MH, Griffin B. (2018) Elucidation of fetal and maternal vancomycin-induced kidney injury using a pregnant rat model, PharmSci 360, November 2018, Washington DC.

Joshi M, Hlukhenka K., Pais G., Prozialeck W, Scheetz M, Griffin B. In vitro evaluation of vancomycin loaded liposomes for its potential of reduced nephrotoxicity in rat epithelial kidney (NRK) cells, ASHP Midyear 2018

Aljefri D, Avedissian S, Rhodes NJ, Postelnick M, Scheetz MH. 1391. Vancomycin Area under the Curve (AUC) to Predict Nephrotoxicity: A systematic Review and Meta-analysis of observational studies. ID Week; San Francisco 2018.

Avedissian S, Liu J, O'Donnell J, Pais G, Becher L, Joshi M, Prozialeck W, Lamar P, Lodise TP, Scheetz MH. 1419. 24-Hour Pharmacokinetic Relationships for Intravenous Vancomycin and Novel Urinary Biomarkers of Acute Kidney Injury. ID Week; San Francisco 2018.

Avedissian S, Rhodes NJ, Liu J, Aljefri D, Postelnick M, Sutton S, Zembower T, Martin D, Pais G, Cruce C, Scheetz MH. 1821. Understanding the components and calculation of the SAAR, Illustrative Data. ID Week; San Francisco 2018.

Cruce C, Postelnick M, Martin D, Sutton S, Wunderink R, Zembower T, Scheetz MH, Rhodes NJ. 209. Impact of a risk-based CAP prescribing guideline paired with antimicrobial stewardship to improve antibiotic prescribing for patients at low risk for drug resistant pathogens. ID Week; San Francisco 2018.

Lee B, Constantino-Corpuz J, Apolinario K, Wang S, Nadler B, Scheetz MH, Rhodes NJ. 1068. Evaluation of Cefazolin versus Anti-Staphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections in Acutely-Ill Adult Patients: Results of a Systematic Review and Meta-Analysis. ID Week; San Francisco 2018.

Liu J, Avedissian S, Pais G, Joshi M, Rhodes NJ, Scheetz MH. 1394. A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid (CSF) and Plasma Concentrations of Cefepime. ID Week; San Francisco 2018.

Liu J, Mercuro N, Davis S, Yarnold P, Patel T, Petty L, Kaye K, Scheetz MH. 1871. Identifying time periods of high and low vancomycin use. ID Week; San Francisco 2018.

Contact Information

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